Bok Gene Summary [Mouse]
Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of mitochondrial depolarization; negative regulation of programmed cell death; and positive regulation of response to endoplasmic reticulum stress. Acts upstream of or within neuron apoptotic process. Located in several cellular components, including bounding membrane of organelle; mitochondrial membrane; and trans-Golgi network membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; gut; retina; and vibrissa dermal component. Orthologous to human BOK (BCL2 family apoptosis regulator BOK). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bok |
| Official Name | BCL2-related ovarian killer [Source:MGI Symbol;Acc:MGI:1858494] |
| Ensembl ID | ENSMUSG00000026278 |
| Bio databases IDs | |
| Aliases | BCL2-related ovarian killer |
| Synonyms | BCL2 family apoptosis regulator BOK, BCL2L9, BCL2-related ovarian killer, Bok1, Bok-BH3, Bokl, matador, mtd |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bok often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- apoptosis regulator
- protein dimerization
- Bcl-2_like
- ubiquitin protein ligase binding
- protein domain specific binding
- protein binding
- receptor binding
- binding protein
- Bcl-2 homology 1 domain
- Bcl-2 homology 2 domain
- Bcl-2 homology 3 domain
- transmembrane domain
- protein homodimerization
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal adenoma
- colorectal adenoma formation
- early-onset preeclampsia
role in cell
- quantity
- production in
- expression in
- apoptosis
- activation in
- phosphorylation in
- autophagy by
- binding in
- translocation in
- 5-fluorouracil resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- trans Golgi network
- mitochondrial membrane
- mitochondrial inner membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bok gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- male gonad development
- cytosolic calcium ion homeostasis
- DNA damage response, signal transduction resulting in induction of apoptosis
- extrinsic apoptotic signaling pathway in absence of ligand
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
- positive regulation of execution phase of apoptosis
- negative regulation of neuron apoptotic process
- negative regulation of necroptosis
- cellular component disassembly involved in apoptotic process
- signal transduction by p53 class mediator resulting in induction of apoptosis
- apoptotic process
- positive regulation of apoptotic process
- regulation of autophagy
- release of cytochrome c from mitochondria
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of mitochondrial depolarization
- positive regulation of intrinsic apoptotic signaling pathway
- protein oligomerization
- neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- endoplasmic reticulum
- nuclear outer membrane
- mitochondrial outer membrane
- mitochondrial inner membrane
- endoplasmic reticulum membrane
- early endosome membrane
- nucleus
- mitochondrial membrane
- cytoplasm
- mitochondrion
- recycling endosome membrane
- trans-Golgi network membrane
- cis-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- BH domain binding
- ubiquitin protein ligase binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- receptor binding