Adgrd1 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytosol and nuclear speck. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; foregut; hypothalamus; skeleton; and white fat. Orthologous to human ADGRD1 (adhesion G protein-coupled receptor D1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgrd1 |
| Official Name | adhesion G protein-coupled receptor D1 [Source:MGI Symbol;Acc:MGI:3041203] |
| Ensembl ID | ENSMUSG00000044017 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor D1 |
| Synonyms | adhesion G protein-coupled receptor D1, E230012M21, E230012M21Rik, GPR133, PGR25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- ectodomain
- GPCR proteolysis site, GPS, motif
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Adgrd1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- adenoma formation
- colon cancer
- epithelial cancer
- oligodendroglioma
- glioma formation
- papillary thyroid carcinoma
- papillary thyroid cancer
- astrocytoma
- Alzheimer disease
regulates
- ADCY
- cyclic AMP
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- membrane
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding