Xirp2 Gene Summary [Mouse]
Enables alpha-actinin binding activity. Involved in positive regulation of protein localization and regulation of actin filament organization. Acts upstream of or within cardiac muscle tissue morphogenesis; cell-cell junction organization; and ventricular septum development. Located in Z disc and cell-cell junction. Is expressed in heart; inner ear; lung; and skeletal muscle. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human XIRP2 (xin actin binding repeat containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Xirp2 |
| Official Name | xin actin-binding repeat containing 2 [Source:MGI Symbol;Acc:MGI:2685198] |
| Ensembl ID | ENSMUSG00000027022 |
| Bio databases IDs | |
| Aliases | xin actin-binding repeat containing 2 |
| Synonyms | 2310003D02RIK, 2310008C07RIK, A530024P18Rik, CMYA3, Gm352, LACS, Myomaxin, Xin2, xin actin-binding repeat containing 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Xirp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- actinin binding
- protein binding
- Xin repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- pancreatic epithelial cancer
- atopic dermatitis
- COVID-19
- Alzheimer disease
- pancreatic carcinoma
- measles
- rotator cuff injury
role in cell
- organization
- surface area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- intercellular junctions
- cytosol
- Z line
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Xirp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular septum development
- actin filament organization
- cell-cell junction organization
- cardiac muscle tissue morphogenesis
Cellular Component
Where in the cell the gene product is active
- Z disc
- focal adhesion
- stress fiber
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- alpha-actinin binding