Sema6d Gene Summary [Mouse]
Enables receptor ligand activity and semaphorin receptor binding activity. Involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and semaphorin-plexin signaling pathway. Acts upstream of or within negative regulation of smooth muscle cell migration; positive regulation of smooth muscle cell migration; and ventricular system development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including cardiovascular system; central nervous system; gut mesenchyme; retina; and spinal ganglion or nerve. Orthologous to human SEMA6D (semaphorin 6D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema6d |
| Official Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D [Source:MGI Symbol;Acc:MGI:2387661] |
| Ensembl ID | ENSMUSG00000027200 |
| Bio databases IDs | |
| Aliases | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D |
| Synonyms | 1110067B02Rik, D330011G23, mKIAA1479, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, semaphorin 6D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema6d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- extracellular domain
- Plexin repeat
- semaphorin receptor binding
- receptor agonist activity
- protein binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema6d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insomnia
- depressive disorder
- restless legs syndrome
- major depression
- Alzheimer disease
- attention deficit hyperactivity disorder
- substance-related disorder
- metabolic syndrome X
- opioid-related disorder
regulates
- AKT
- ERK
- agar
role in cell
- migration
- proliferation
- collapse
- colony formation by
- migration by
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema6d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular system development
- negative chemotaxis
- smooth muscle cell migration
- neural crest cell migration
- axon guidance
- negative regulation of smooth muscle cell migration
- positive regulation of smooth muscle cell migration
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding