Zfp106 Gene Summary [Mouse]
Enables SH3 domain binding activity and opioid peptide activity. Acts upstream of or within insulin receptor signaling pathway. Located in cytosol and membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart and pericardium; and musculature. Used to study amyotrophic lateral sclerosis. Orthologous to human ZNF106 (zinc finger protein 106). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp106 |
| Official Name | zinc finger protein 106 [Source:MGI Symbol;Acc:MGI:1270153] |
| Ensembl ID | ENSMUSG00000027288 |
| Bio databases IDs | |
| Aliases | zinc finger protein 106 |
| Synonyms | Cd-1, D2Dcr28, EyeLinc12, H3a, SH3BP3, sirm, ZFP106, ZINC FINGER protein 106, ZNF474 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp106 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- opioid peptide
- SH3-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- rotator cuff injury
- right bundle branch block
- paralysis
- ataxia
- muscular atrophy
phenotypes
- abnormal axon morphology
- abnormal external male genitalia morphology
- abnormal gait
- abnormal gastrocnemius morphology
- abnormal lumbar dorsal root ganglion morphology
- abnormal mitochondrial ATP synthesis coupled electron transport
- abnormal mitochondrial physiology
- abnormal muscle electrophysiology
- abnormal muscle physiology
- abnormal physical strength
- abnormal redox activity
- abnormal skeletal muscle fiber type ratio
- abnormal skeletal muscle morphology
- abnormal soleus morphology
- abnormal spinal cord morphology
- astrocytosis
- axon degeneration
- cachexia
- centrally nucleated skeletal muscle fibers
- chromatolysis
- decreased body weight
- decreased gastrocnemius weight
- decreased grip strength
- decreased mean corpuscular hemoglobin
- decreased motor neuron number
- decreased skeletal muscle fiber number
- decreased soleus weight
- decreased tibialis anterior weight
- gliosis
- hypoactivity
- impaired coordination
- impaired limb coordination
- increased circulating calcium level
- increased spinal cord apoptosis
- increased thermal nociceptive threshold
- increased variability of skeletal muscle fiber size
- kyphosis
- limb grasping
- microgliosis
- motor neuron degeneration
- neurodegeneration
- positive geotaxis
- premature death
- skeletal muscle atrophy
- skeletal muscle fiber atrophy
- skeletal muscle fiber degeneration
- skeletal muscle fibrosis
- small L4 dorsal root ganglion
- small L5 dorsal root ganglion
- small dorsal root ganglion
- tremors
- weight loss
role in cell
- accumulation
- deletion
- processing in
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- cytosol
- nuclear speckles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp106 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- membrane
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- SH3 domain binding