Smox Gene Summary [Mouse]
Enables polyamine oxidase activity. Acts upstream of or within spermine catabolic process. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including cerebral cortex; extraembryonic component; and placenta. Orthologous to human SMOX (spermine oxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smox |
| Official Name | spermine oxidase [Source:MGI Symbol;Acc:MGI:2445356] |
| Ensembl ID | ENSMUSG00000027333 |
| Bio databases IDs | |
| Aliases | spermine oxidase |
| Synonyms | B130066H01RIK, C20orf16, PAO, PAO-1, PAOH, PAOH1, Polyamine oxidase 1, SMO, Spermine oxidase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- spermine oxidase
- polyamine oxidase
- enzyme
- Flavin containing amine oxidoreductase
Pathways
Biological processes and signaling networks where the Smox gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cell carcinoma
- renal cell cancer
- early missed abortion
- pemphigus vulgaris
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- dementia
- male pattern hair loss
- dental disorder
role in cell
- apoptosis
- production in
- growth
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xenobiotic metabolic process
- polyamine biosynthetic process
- spermine catabolic process
- polyamine catabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- polyamine oxidase activity
- norspermine:oxygen oxidoreductase activity
- N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity
- spermine:oxygen oxidoreductase (spermidine-forming) activity