Tra2b Gene Summary [Mouse]
Predicted to enable RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Involved in regulation of RNA splicing. Acts upstream of or within cerebral cortex regionalization; embryonic brain development; and positive regulation of mRNA splicing, via spliceosome. Located in nuclear inner membrane. Is expressed in several structures, including brain; central nervous system ganglion; extraembryonic component; olfactory epithelium; and retina. Orthologous to human TRA2B (transformer 2 beta homolog). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tra2b |
| Official Name | transformer 2 beta [Source:MGI Symbol;Acc:MGI:106016] |
| Ensembl ID | ENSMUSG00000022858 |
| Bio databases IDs | |
| Aliases | transformer 2 beta |
| Synonyms | 5730405G21RIK, D16Ertd266e, Htra2-beta, Htra2-β, PPP1R156, Ra301/Tra2 β, SFRS10, SIG-41, Silg41, SRFS10, Srsf10, Tra2-B1, TRA2-BETA, TRA2-beta3, TRA2-β, TRAN2B, transformer 2 beta, transformer 2 beta homolog, transformer 2 β, transformer 2 β homolog |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tra2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- protein domain specific binding
- Occluded RNA-recognition motif
- protein binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic kidney disease
- postmenopausal osteoporosis
- survival
- organismal death
- plexiform neurofibroma
- breast carcinoma
- osteonecrosis
role in cell
- expression in
- apoptosis
- proliferation
- invasion by
- splicing by
- response by
- alternative splicing by
- lipogenesis by
- alternative splicing in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- spliceosomes
- inner nuclear membrane
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tra2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- cellular response to glucose stimulus
- positive regulation of nuclear mRNA splicing, via spliceosome
- regulation of alternative nuclear mRNA splicing, via spliceosome
- regulation of RNA splicing
- cerebral cortex regionalization
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear inner membrane
- spliceosomal complex
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- identical protein binding
- protein domain specific binding
- RNA binding
- protein binding
- mRNA binding