Usp50 Gene Summary [Mouse]
Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within positive regulation of NLRP3 inflammasome complex assembly; positive regulation of interleukin-1 beta production; and positive regulation of interleukin-18 production. Predicted to be located in centrosome; cytoplasm; and nucleus. Predicted to be active in cytosol; midbody; and postsynaptic density. Orthologous to human USP50 (ubiquitin specific peptidase 50). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Usp50 |
| Official Name | ubiquitin specific peptidase 50 [Source:MGI Symbol;Acc:MGI:1922333] |
| Ensembl ID | ENSMUSG00000027364 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 50 |
| Synonyms | 1700086G18Rik, 4930511O11Rik, LOC107984741, RGD1564751, ubiquitin specific peptidase 50 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp50 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp50 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp50 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- endosome organization
- nuclear speck organization
- positive regulation of interleukin-18 production
- Ras protein signal transduction
- positive regulation of NLRP3 inflammasome complex assembly
- positive regulation of cysteine-type endopeptidase activity
- positive regulation of interleukin-1 beta production
- protein K48-linked deubiquitination
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- nucleus
- centrosome
- cytoplasm
- dendritic spine
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- small conjugating protein-specific protease activity