Serp1 Gene Summary [Mouse]
Acts upstream of or within several processes, including endoplasmic reticulum unfolded protein response; positive regulation of organ growth; and positive regulation of peptide hormone secretion. Predicted to be located in cytoplasmic microtubule. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including jaw and orbito-sphenoid. Orthologous to human SERP1 (stress associated endoplasmic reticulum protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serp1 |
| Official Name | stress-associated endoplasmic reticulum protein 1 [Source:MGI Symbol;Acc:MGI:92638] |
| Ensembl ID | ENSMUSG00000027808 |
| Bio databases IDs | |
| Aliases | stress-associated endoplasmic reticulum protein 1 |
| Synonyms | D3Ucla1, LOC101928061, RAMP4, stress-associated endoplasmic reticulum protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Serp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane domain
- Ribosome associated membrane protein RAMP4
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
role in cell
- invasion
- cell death
- organization
- endoplasmic reticulum stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Serp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- positive regulation of translation
- positive regulation of growth hormone secretion
- insulin secretion
- post-embryonic development
- protein glycosylation
- positive regulation of organ growth
- muscle organ morphogenesis
- glucose metabolic process
- plasma membrane organization
- skeletal system development
- endoplasmic reticulum unfolded protein response
- positive regulation of insulin secretion
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- endoplasmic reticulum
- cytoplasmic microtubule
- ribosome
Molecular Function
What the gene product does at the molecular level
- protein binding