Epha8 Gene Summary [Mouse]
Enables GPI-linked ephrin receptor activity and growth factor binding activity. Involved in several processes, including ephrin receptor signaling pathway; neuron development; and positive regulation of intracellular signal transduction. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus. Located in neuron projection and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human EPHA8 (EPH receptor A8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epha8 |
| Official Name | Eph receptor A8 [Source:MGI Symbol;Acc:MGI:109378] |
| Ensembl ID | ENSMUSG00000028661 |
| Bio databases IDs | |
| Aliases | Eph receptor A8 |
| Synonyms | EEK, EK3, EPH receptor A8, HEK3, LOC60589, mKIAA1459 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epha8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SAM domain
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- GPI-linked ephrin receptor
- Sterile alpha motif
- ligand-binding domain
- SAM domain (Sterile alpha motif)
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- growth factor binding
- Ligand Binding Domain of Ephrin Receptors
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- Purple acid Phosphatase, N-terminal domain
- ephrin receptor
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- FN3
- tyrosine kinase domain
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the Epha8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- soft tissue sarcoma cancer
- rhabdomyosarcoma
role in cell
- migration
- induction in
- adhesion
- retraction
- attachment
- guidance
- morphogenesis
- distribution
- contact repulsion
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- neuromuscular junctions
- neurites
- nerve ending
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Epha8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- axon guidance
- cell adhesion
- positive regulation of MAPK cascade
- protein phosphorylation
- cellular response to follicle-stimulating hormone stimulus
- regulation of cell adhesion mediated by integrin
- ephrin receptor signaling pathway
- substrate-dependent cell migration
- regulation of cell adhesion
- neuron remodeling
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- dendrite
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- growth factor binding
- GPI-linked ephrin receptor activity
- ephrin receptor activity
- transmembrane-ephrin receptor activity