Pabpc1l Gene Summary [Mouse]
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Acts upstream of or within RNA metabolic process; nucleus localization; and oocyte maturation. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in early conceptus and gonad. Orthologous to human PABPC1L (poly(A) binding protein cytoplasmic 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pabpc1l |
| Official Name | poly(A) binding protein, cytoplasmic 1-like [Source:MGI Symbol;Acc:MGI:1922908] |
| Ensembl ID | ENSMUSG00000054582 |
| Bio databases IDs | |
| Aliases | poly(A) binding protein, cytoplasmic 1-like |
| Synonyms | 1810053B01Rik, C20orf119, dJ1069P2.3, EPAB, LOC684530, PABPC1L1, poly(A) binding protein cytoplasmic 1 like, poly(A) binding protein, cytoplasmic 1-like, RGD1563142 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pabpc1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- polyadenylate binding protein, human types 1, 2, 3, 4 family
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- poly(A) binding protein
- Poly-adenylate binding protein, unique domain
- C-terminal domain of Poly(A)-binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- female infertility
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
- squamous cell lung cancer
- colorectal carcinomagenesis
- urothelial bladder carcinoma
- transitional cell bladder cancer
- hepatocellular carcinoma
role in cell
- expression in
- phosphorylation in
- function
- number
- abnormal morphology
- maturation
- remodeling
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pabpc1l gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- poly(A) RNA binding
- poly(U) RNA binding
- mRNA 3'-UTR binding