LOC100910771 Gene Summary [Rat]
Enables several functions, including ATP binding activity; enzyme binding activity; and protein kinase activity. Involved in several processes, including positive regulation of cell size; positive regulation of intracellular signal transduction; and positive regulation of vascular associated smooth muscle cell migration. Predicted to be located in plasma membrane and postsynaptic density. Predicted to be part of ATAC complex. Predicted to be active in cytosol and endoplasmic reticulum membrane. Used to study arteriosclerosis. Biomarker of chronic kidney disease and myocardial infarction. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC100910771 |
| Official Name | mitogen-activated protein kinase kinase kinase 7-like [Source:RGD Symbol;Acc:6496502] |
| Ensembl ID | ENSRNOG00000005724 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 7-like |
| Synonyms | B430101B05, CSCF, FMD2, Map3k7 predicted, MEKK7, mitogen-activated protein kinase kinase kinase 7, TAK1, TGF1a, Tgf beta Activated Kinase1, Tgf β Activated Kinase1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc100910771 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- punt binding
- protein kinase
- ATP-binding domain
- ATP binding
- transcription factor binding
- enzyme
- Protein kinase domain
- identical protein binding
- receptor tyrosine kinase binding
- MAP kinase kinase kinase kinase
- MAP kinase
- Tyrosine kinase, catalytic domain
- ubiquitin protein ligase binding
- Protein kinase (unclassified specificity)
- protein kinase binding
- autoinhibitory protein domain
- Protein tyrosine and serine/threonine kinase
- ubiquitin binding
- protein binding
- MAP kinase kinase kinase
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- MAP kinase kinase
- kinase domain
- serine/threonine phosphorylation motif
- Protein Kinases, catalytic domain
Pathways
Biological processes and signaling networks where the Loc100910771 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- cancer
- liver neoplasia
- epithelial neoplasia
- epithelial cancer
- neoplasia
- liver cancer
- cardiospondylocarpofacial syndrome
- acute myeloid leukemia
- hypoplasia
role in cell
- phosphorylation in
- activation in
- molecular cleavage in
- cell viability
- expression in
- induction in
- degradation in
- quantity
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- ribosome
- Nucleus
- Plasma Membrane
- cytosol
- endoplasmic reticulum membrane
- endosomal membrane
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc100910771 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- I-kappaB phosphorylation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- Fc-epsilon receptor signaling pathway
- transforming growth factor beta receptor signaling pathway
- positive regulation of cell cycle
- JNK cascade
- stimulatory C-type lectin receptor signaling pathway
- cytoplasmic pattern recognition receptor signaling pathway
- MAPK cascade
- inflammatory response
- chromatin remodeling
- MyD88-dependent toll-like receptor signaling pathway
- immune response
- positive regulation of cell size
- cellular response to tumor necrosis factor
- cellular response to hypoxia
- T cell receptor signaling pathway
- stress-activated MAPK cascade
- positive regulation of interleukin-2 production
- positive regulation of macroautophagy
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- p38MAPK cascade
- toll-like receptor 4 signaling pathway
- anoikis
- I-kappaB kinase/NF-kappaB cascade
- defense response to bacterium
- negative regulation of gene expression
- positive regulation of T cell cytokine production
- toll-like receptor 3 signaling pathway
- interleukin-1-mediated signaling pathway
- TRIF-dependent toll-like receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- histone kinase activity
- protein serine/threonine kinase activity
- type II transforming growth factor beta receptor binding
- MAP kinase kinase kinase kinase activity
- transcription coactivator binding
- magnesium ion binding
- ATP binding
- scaffold protein binding
- ubiquitin protein ligase binding
- protein binding
- MAP kinase activity
- MAP kinase kinase kinase activity
- receptor tyrosine kinase binding