Smarcc2 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within forebrain neuron fate commitment and negative regulation of transcription by RNA polymerase II. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in central nervous system; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 8. Orthologous to human SMARCC2 (SWI/SNF related BAF chromatin remodeling complex subunit C2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smarcc2 |
| Official Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 [Source:MGI Symbol;Acc:MGI:1915344] |
| Ensembl ID | ENSMUSG00000025369 |
| Bio databases IDs | |
| Aliases | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 |
| Synonyms | 5930405J04RIK, BAF170, CRACC2, CSS8, LOC685179, Rsc8, SWI/SNF related BAF chromatin remodeling complex subunit C2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smarcc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- SWIRM-associated domain at the N-terminal
- SWIRM-associated domain at the C-terminal
- SWIRM domain
- chromatin binding
- protein binding
Pathways
Biological processes and signaling networks where the Smarcc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- AMPK Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Gap Junction Signaling
- Glucocorticoid Receptor Signaling
- Hereditary Breast Cancer Signaling
- RAR Activation
- Relaxin Signaling
- Role of BRCA1 in DNA Damage Response
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Coffin-Siris syndrome type 8
- renal clear cell adenocarcinoma
- renal clear cell cancer
- autosomal dominant mental retardation type 12
- neurodevelopmental disorder
- Coffin-Siris syndrome
- mental retardation
role in cell
- expression in
- migration
- proliferation
- survival
- accumulation in
- disassembly
- disruption
- invasion by
- non-homologous end joining in
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- nucleoplasm
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smarcc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- nervous system development
- positive regulation of cell differentiation
- positive regulation of myoblast differentiation
- regulation of nucleotide-excision repair
- nucleosome disassembly
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of T cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- npBAF complex
- nuclear matrix
- macromolecular complex
- nBAF complex
- brahma complex
- kinetochore
- RSC complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- histone binding
- nucleosomal DNA binding