Anapc5 Gene Summary [Mouse]
Predicted to enable protein phosphatase binding activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be located in nucleus and spindle. Predicted to be part of anaphase-promoting complex. Is expressed in brain; cerebellum; and cerebral cortex. Orthologous to human ANAPC5 (anaphase promoting complex subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anapc5 |
| Official Name | anaphase-promoting complex subunit 5 [Source:MGI Symbol;Acc:MGI:1929722] |
| Ensembl ID | ENSMUSG00000029472 |
| Bio databases IDs | |
| Aliases | anaphase-promoting complex subunit 5 |
| Synonyms | 2510006G12Rik, ANAPHASE PROMOTING COMPLEX 5, anaphase-promoting complex subunit 5, Anpc5, APC5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Anapc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase binding
- Anaphase-promoting complex subunit 5
Pathways
Biological processes and signaling networks where the Anapc5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- non-small cell lung cancer
- systemic autoimmune syndrome
regulates
- cyclin
role in cell
- growth
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Anapc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of meiotic cell cycle
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of mitotic metaphase/anaphase transition
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- anaphase-promoting complex
- spindle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding