Ddx54 Gene Summary [Mouse]
Predicted to enable several functions, including RNA helicase activity; nuclear estrogen receptor binding activity; and transcription corepressor activity. Predicted to be involved in rRNA processing. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in nucleolus. Is expressed in several structures, including branchial arch; hemolymphoid system gland; limb; male reproductive gland or organ; and tongue. Orthologous to human DDX54 (DEAD-box helicase 54). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx54 |
| Official Name | DEAD box helicase 54 [Source:MGI Symbol;Acc:MGI:1919240] |
| Ensembl ID | ENSMUSG00000029599 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 54 |
| Synonyms | 2410015A15Rik, DEAD-box helicase 54, DP97, RGD1562539 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx54 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-repressor
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- receptor binding
- estrogen receptor binding
- Helicase conserved C-terminal domain
- RNA helicase
- DBP10CT (NUC160) domain
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- lung cancer
- colon cancer
- pancreatic carcinoma
- pancreatic epithelial cancer
role in cell
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx54 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA metabolic process
- negative regulation of transcription, DNA-dependent
- RNA processing
- rRNA processing
- intracellular estrogen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- Golgi apparatus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- RNA helicase activity
- transcription corepressor activity
- estrogen receptor binding
- receptor binding