Ogg1 Gene Summary [Mouse]
Enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity and microtubule binding activity. Acts upstream of or within base-excision repair. Located in mitochondrion and nucleus. Is expressed in junctional zone and labyrinthine zone. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ogg1 |
| Official Name | 8-oxoguanine DNA-glycosylase 1 [Source:MGI Symbol;Acc:MGI:1097693] |
| Ensembl ID | ENSMUSG00000030271 |
| Bio databases IDs | |
| Aliases | 8-oxoguanine DNA-glycosylase 1 |
| Synonyms | 8-oxoguanine DNA glycosylase, 8-oxoguanine DNA-glycosylase 1, FPG, HMMH, HOGG1, Mmh, MUTM, OGG1/2, OGH1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ogg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA N-glycosylase
- nucleic acid binding
- enzyme binding
- enzyme
- protein binding
- endonuclease III
- 8-oxoguanine DNA-glycosylase (ogg)
- sequence-specific DNA binding
- DNA binding
- HhH-GPD superfamily base excision DNA repair protein
- microtubule binding
- ENDO3c
- endonuclease
- oxidized base lesion DNA N-glycosylase
- damaged DNA binding
- AlkA N-terminal domain
- double-stranded DNA binding
- DNA-formamidopyrimidine glycosylase
Pathways
Biological processes and signaling networks where the Ogg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- advanced cancer
- cancer
- Alzheimer disease
- prostate cancer
- neurodegeneration
- renal clear cell adenocarcinoma
- renal clear cell cancer
- adenoma formation
role in cell
- expression in
- phosphorylation in
- migration
- apoptosis
- proliferation
- activation in
- number
- production in
- growth
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microsomal fraction
- nuclear fraction
- chromatin fraction
- nuclear matrix fraction
- inner membrane
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
- nucleoli
- nuclear speckles
- nuclear matrix
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ogg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- base-excision repair
- base-excision repair, AP site formation
- response to radiation
- nucleotide-excision repair
- regulation of transcription, DNA-dependent
- response to xenobiotic stimulus
- hypomethylation of CpG island
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- response to light stimulus
- depurination
- depyrimidination
- response to oxidative stress
- response to ethanol
- negative regulation of apoptotic process
- response to folic acid
- cellular response to cadmium ion
- response to estradiol stimulus
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- nuclear speck
- cytosol
- nuclear matrix
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- endonuclease activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
- damaged DNA binding
- oxidized purine DNA binding
- enzyme binding
- microtubule binding
- oxidized purine base lesion DNA N-glycosylase activity