Il21r Gene Summary [Mouse]
Enables cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in lung; mandible; and orbito-sphenoid. Human ortholog(s) of this gene implicated in B-cell lymphoma (multiple); Crohn's disease; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and immunodeficiency 56. Orthologous to human IL21R (interleukin 21 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Il21r |
| Official Name | interleukin 21 receptor [Source:MGI Symbol;Acc:MGI:1890475] |
| Ensembl ID | ENSMUSG00000030745 |
| Bio databases IDs | |
| Aliases | interleukin 21 receptor |
| Synonyms | CD360, IL21R alpha, IL21R α, IMD56, interleukin 21 receptor, NILR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il21r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- FN3
- protein binding
- cytokine receptor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il21r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- infection
- experimental autoimmune encephalomyelitis
- cancer
- head and neck squamous cell cancer
- rheumatoid arthritis
- primary biliary cirrhosis
- insulin-dependent diabetes mellitus
- immunodeficiency
role in cell
- proliferation
- expression in
- migration
- differentiation
- formation
- number
- activation in
- production in
- quantity
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il21r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-21-mediated signaling pathway
- cytokine-mediated signaling pathway
- immunoglobulin mediated immune response
- natural killer cell activation
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-21 receptor activity
- transmembrane signaling receptor activity
- protein binding
- cytokine receptor activity