Irx5 Gene Summary [Mouse]
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within neuron differentiation; regulation of gene expression; and regulation of heart rate. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Orthologous to human IRX5 (iroquois homeobox 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irx5 |
| Official Name | Iroquois homeobox 5 [Source:MGI Symbol;Acc:MGI:1859086] |
| Ensembl ID | ENSMUSG00000031737 |
| Bio databases IDs | |
| Aliases | Iroquois homeobox 5 |
| Synonyms | HMMS, Iroquois homeobox 5, IRX-2a, IRXB2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irx5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Motif in Iroquois-class homeodomain proteins (only)
- double-stranded DNA binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic adenocarcinoma
- glioblastoma
- glioblastoma cancer
- pancreatic epithelial cancer
- Hamamy syndrome
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
- Richter syndrome
- Hutchinson-Gilford progeria syndrome
role in cell
- expression in
- proliferation
- differentiation
- development
- maturation
- generation
- expansion
- abnormal morphology
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Irx5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gonad development
- neuron differentiation
- embryonic cranial skeleton morphogenesis
- cell development
- visual perception
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- vitamin D binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity