Cxcl14 Gene Summary [Mouse]
Predicted to enable chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of another organism. Acts upstream of or within inner ear development; negative regulation of myoblast differentiation; and positive regulation of natural killer cell chemotaxis. Predicted to be located in Golgi apparatus. Is expressed in several structures, including embryo ectoderm; eye; genitourinary system; limb; and skin. Orthologous to human CXCL14 (C-X-C motif chemokine ligand 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cxcl14 |
| Official Name | chemokine (C-X-C motif) ligand 14 [Source:MGI Symbol;Acc:MGI:1888514] |
| Ensembl ID | ENSMUSG00000021508 |
| Bio databases IDs | |
| Aliases | chemokine (C-X-C motif) ligand 14 |
| Synonyms | 1110031L23Rik, 1200006I23Rik, BMAC, bolekine, BRAK, C-X-C motif chemokine ligand 14, KEC, KS1, MIP-2g, MIP2gamma, Mip2 γ, NJAC, SCYB14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcl14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta strand or sheet
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- alpha helix
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Cxcl14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- non-small cell lung cancer
- hyperglycemia
- metastasis
- hypertrophic scarring
- Duchenne muscular dystrophy
- angiomatosis
- benign neoplasia
- squamous cell cancer of the oral cavity
- rheumatoid arthritis
role in cell
- activation in
- expression in
- production in
- phosphorylation in
- migration
- differentiation
- proliferation
- depolarization
- binding
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cxcl14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- signal transduction
- cell-cell signaling
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemokine activity