Pard6a Gene Summary [Mouse]
Enables GTP-dependent protein binding activity and small GTPase binding activity. Involved in cell-cell junction maintenance and positive regulation of protein secretion. Acts upstream of or within negative regulation of protein phosphorylation. Located in bicellular tight junction; cell cortex; and nucleus. Is expressed in several structures, including 2-cell stage conceptus; brain; genitourinary system; gut; and lung. Orthologous to human PARD6A (par-6 family cell polarity regulator alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Pard6a |
| Official Name | par-6 family cell polarity regulator alpha [Source:MGI Symbol;Acc:MGI:1927223] |
| Ensembl ID | ENSMUSG00000005699 |
| Bio databases IDs | |
| Aliases | par-6 family cell polarity regulator alpha |
| Synonyms | 0710008C04Rik, 2610010A15RIK, MPAR6, PAR6, PAR-6A, PAR6alpha, PAR6C, par-6 family cell polarity regulator alpha, par-6 family cell polarity regulator α, TAX40, TIP-40 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pard6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- GTP-dependent protein binding
- canonical PDZ domain
- enzyme binding
- protein binding
- PDZ domain
- PB1
- Phox and Bem1 domain
Pathways
Biological processes and signaling networks where the Pard6a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplastic cell transformation
role in cell
- expression in
- phosphorylation in
- formation
- growth
- binding in
- inhibition in
- polarization
- loss
- invasion by
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- axon component
- Cytoplasm
- perinuclear region
- cell cortex
- Nucleus
- centrosome
- cell-cell contacts
- cytosol
- primary cilia
- membrane ruffles
- spindle pole
- nuclear speckles
- growth cone
- tight junctions
- mitotic spindle
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pard6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of cellular localization
- centrosome cycle
- negative regulation of protein phosphorylation
- establishment or maintenance of epithelial cell apical/basal polarity
- establishment or maintenance of cell polarity
- viral reproduction
- positive regulation of protein secretion
- cell-cell junction maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- tight junction
- centrosome
- occluding junction
- centriolar satellite
- cell cortex
- ruffle
- cytosol
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- GTP-dependent protein binding