Tie1 Gene Summary [Mouse]
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in circulatory system development; response to retinoic acid; and tissue remodeling. Acts upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tie1 |
| Official Name | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [Source:MGI Symbol;Acc:MGI:99906] |
| Ensembl ID | ENSMUSG00000033191 |
| Bio databases IDs | |
| Aliases | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 |
| Synonyms | D430008P04Rik, JTK14, LMPHM11, TIE, tyrosine kinase with immunoglobulin-like and EGF-like domains 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tie1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Furin-like cysteine rich region
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- EGF_CA
- Laminin-type epidermal growth factor-like domai
- Immunoglobulin like
- intracellular domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- endodomain
- extracellular domain
- Protein kinase (unclassified specificity)
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- ectodomain
- Human growth factor-like EGF
- Immunoglobulin I-set domain
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- FN3
- transmembrane domain
Pathways
Biological processes and signaling networks where the Tie1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastrointestinal stromal tumor
- bleeding
- leiomyomatosis
- schwannoma
- hyperplasia
- collagen-induced arthritis
- edema
- gastrointestinal stromal neoplasia
- lymphatic malformation 11
role in cell
- migration
- expression in
- survival
- abnormal morphology
- fusion
- development
- endothelial mesenchymal transition
- assembly
- radioresistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tie1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- aortic valve morphogenesis
- signal transduction
- multicellular organismal development
- mesoderm development
- transmembrane receptor protein tyrosine kinase signaling pathway
- plasma membrane fusion
- lymphatic endothelial cell differentiation
- vasculogenesis
- positive regulation of angiogenesis
- patterning of lymph vessels
- tissue remodeling
- response to retinoic acid
- in utero embryonic development
- angiogenesis
- regulation of endothelial cell proliferation
- positive regulation of kinase activity
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity