Gde1 Gene Summary [Mouse]
Enables glycerophosphodiester phosphodiesterase activity; glycerophosphoinositol glycerophosphodiesterase activity; and lysophospholipase activity. Involved in ethanolamine metabolic process. Acts upstream of or within N-acylethanolamine metabolic process and phospholipid metabolic process. Located in plasma membrane. Is expressed in several structures, including ganglia; gut; lower urinary tract; lung; and nasal cavity epithelium. Orthologous to human GDE1 (glycerophosphodiester phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gde1 |
| Official Name | glycerophosphodiester phosphodiesterase 1 [Source:MGI Symbol;Acc:MGI:1891827] |
| Ensembl ID | ENSMUSG00000033917 |
| Bio databases IDs | |
| Aliases | glycerophosphodiester phosphodiesterase 1 |
| Synonyms | 1200003M13Rik, 363E6.2, glycerophosphodiester phosphodiesterase 1, Glycerophosphoryl diester phosphodiesterase, Membrane interacting protein of Rgs16, MIR16, RGS16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gde1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycerophosphoinositol glycerophosphodiesterase
- lysophospholipase
- Glycerophosphoryl diester phosphodiesterase family
- enzyme
- protein binding
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- glycerophosphodiester phosphodiesterase
- phosphoric diester hydrolase
Pathways
Biological processes and signaling networks where the Gde1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- apical compartment
- perinuclear region
- intracellular membranes
- cellular membrane
- sinusoidal membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gde1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerophospholipid catabolic process
- ethanolamine metabolic process
- lipid metabolic process
- phospholipid metabolic process
- N-acylethanolamine metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- glycerophosphoinositol glycerophosphodiesterase activity
- protein binding
- metal ion binding
- glycerophosphodiester phosphodiesterase activity