Rgs16 Gene Summary [Mouse]
Enables GTPase activator activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of GTPase activity. Located in membrane. Is expressed in several structures, including central nervous system; limb mesenchyme; lip; neural retina; and skeletal musculature. Orthologous to human RGS16 (regulator of G protein signaling 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs16 |
| Official Name | regulator of G-protein signaling 16 [Source:MGI Symbol;Acc:MGI:108407] |
| Ensembl ID | ENSMUSG00000026475 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 16 |
| Synonyms | A28-RGS14, A28-RGS14P, Regulator of g-protein signaling, regulator of G-protein signaling 16, Rgs14, RGS-R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgs16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- calmodulin binding
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
- GTPase Activating Protein domain
Pathways
Biological processes and signaling networks where the Rgs16 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- fibrosis
- pulmonary fibrosis
- hepatic steatosis
- epileptic seizure
- insomnia
- Sézary syndrome
- alpha-1-antitrypsin deficiency
- infection by parasite
role in cell
- phosphorylation in
- cell viability
- proliferation
- growth
- cell death
- migration
- function
- accumulation
- aggregation
- exclusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- perinuclear region
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgs16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- visual perception
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- GTPase activity
- GTPase activator activity