SOCS7 Gene Summary [Human]
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within several processes, including brain development; fat cell differentiation; and insulin receptor signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SOCS7 |
| Official Name | suppressor of cytokine signaling 7 [Source:HGNC Symbol;Acc:HGNC:29846] |
| Ensembl ID | ENSG00000274211 |
| Bio databases IDs | |
| Aliases | suppressor of cytokine signaling 7, Nck, Ash and phospholipase C binding protein, NCK-associated protein 4 |
| Synonyms | 2310063P06Rik, NAP4, NCKAP4, Suppressor of cytokine signaling 7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SOCS7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- protein binding activity, bridging
- SOCS
- Src homology 2 (SH2) domain
- protein binding
Pathways
Biological processes and signaling networks where the SOCS7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- hypoglycemia
- growth failure
- hydrocephalus
- macrocephaly
- bleeding
- serous ovarian cancer
- high-grade serous ovarian carcinoma
- high-grade serous epithelial ovarian or fallopian tube or primary peritoneal cancer
role in cell
- proliferation
- cell viability
- expression in
- differentiation
- cell cycle progression
- migration
- ubiquitination in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SOCS7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- phosphatidylinositol phosphorylation
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- phosphatidylinositol 3-kinase complex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding
- 1-phosphatidylinositol-3-kinase regulator activity