Hoxa4 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification and embryonic skeletal system morphogenesis. Predicted to be located in nuclear body. Predicted to be active in nucleoplasm. Is expressed in several structures, including embryo mesenchyme; gut; nervous system; respiratory system; and skin. Orthologous to human HOXA4 (homeobox A4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxa4 |
| Official Name | homeobox A4 [Source:MGI Symbol;Acc:MGI:96176] |
| Ensembl ID | ENSMUSG00000000942 |
| Bio databases IDs | |
| Aliases | homeobox A4 |
| Synonyms | homeo box A4, HOX1, Hox-1.4, HOX1D, Hox1r2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxa4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
- DNA binding
Pathways
Biological processes and signaling networks where the Hoxa4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart disease
- systolic heart failure
- preeclampsia
- abdominal aortic aneurysm
- myocardial infarction
role in cell
- proliferation
- expression in
- quantity
- migration
- cell spreading
- binding in
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear region
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxa4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterior/posterior pattern specification
- anatomical structure morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- embryonic skeletal system morphogenesis
Cellular Component
Where in the cell the gene product is active
- nuclear body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity