Adgrg6 Gene Summary [Mouse]
Enables laminin binding activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; heart trabecula formation; and myelination in peripheral nervous system. Predicted to be located in cell surface and cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including embryo mesenchyme; heart; musculoskeletal system; urinary system; and vascular system. Used to study idiopathic scoliosis. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgrg6 |
| Official Name | adhesion G protein-coupled receptor G6 [Source:MGI Symbol;Acc:MGI:1916151] |
| Ensembl ID | ENSMUSG00000039116 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor G6 |
| Synonyms | 1190004A11RIK, adhesion G protein-coupled receptor G6, APG1, DREG, Gm222, GPR126, LCCS9, LOC681235, PR126, PS1TP2, VIGR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrg6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- endopeptidase
- CUB
- LamG
- laminin binding
- extracellular matrix binding
- collagen binding
- GPCR proteolysis site, GPS, motif
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Adgrg6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- severe preeclampsia
- breast cancer
- chronic obstructive pulmonary disease
- idiopathic scoliosis
- airway obstruction
- epithelial thyroid cancer
- scoliosis
- lethal congenital contracture syndrome type 9
regulates
- cyclic AMP
role in cell
- proliferation
- recruitment
- regeneration
- differentiation
- abnormal morphology
- sorting
- myelination
- fasciculation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrg6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Schwann cell differentiation
- myelination in peripheral nervous system
- G-protein coupled receptor signaling pathway
- nervous system development
- myelination
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cAMP-mediated signaling
- heart trabecula formation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- extracellular matrix binding
- collagen binding
- endopeptidase activity
- laminin binding