Cherp Gene Summary [Mouse]
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in intracellular calcium ion homeostasis; positive regulation of calcineurin-NFAT signaling cascade; and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in perinuclear region of cytoplasm. Is expressed in embryo and extraembryonic component. Orthologous to human CHERP (calcium homeostasis endoplasmic reticulum protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cherp |
| Official Name | calcium homeostasis endoplasmic reticulum protein [Source:MGI Symbol;Acc:MGI:106417] |
| Ensembl ID | ENSMUSG00000052488 |
| Bio databases IDs | |
| Aliases | calcium homeostasis endoplasmic reticulum protein |
| Synonyms | 5730408I11Rik, calcium homeostasis endoplasmic reticulum protein, D8Wsu96e, DAN16, ERPROT213-21, SCAF6, SRA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cherp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-patch domain
- ion channel binding
- VHS, ENTH and ANTH domain superfamily
- CID domain
- Surp module
- protein binding
- Suppressor-of-White-APricot splicing regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- sarcoplasmic reticulum
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cherp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- nervous system development
- positive regulation of calcineurin-NFAT signaling cascade
- RNA processing
- release of sequestered calcium ion into cytosol
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- sarcoplasmic reticulum membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- ion channel binding