Dap Gene Summary [Mouse]
Predicted to enable death domain binding activity and ribosome binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of autophagy; and regulation of gene expression. Predicted to act upstream of or within apoptotic process. Is expressed in early conceptus; pancreas; and skeleton. Orthologous to human DAP (death associated protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dap |
| Official Name | death-associated protein [Source:MGI Symbol;Acc:MGI:1918190] |
| Ensembl ID | ENSMUSG00000039168 |
| Bio databases IDs | |
| Aliases | death-associated protein |
| Synonyms | 4921531N22Rik, DAP1, death-associated protein, DEATH ASSOCIATED protein1, RAP7A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death-associated protein
- transcription regulator
- protein domain specific binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- mature B-cell neoplasia
- inflammatory bowel disease
- ulcerative colitis
- plasma cell neoplasm
- B cell cancer
- COVID-19
- pulmonary tuberculosis
- Crohn disease
role in cell
- apoptosis
- growth
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- negative regulation of transcription, DNA-dependent
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of autophagy
- autophagy
- cellular response to amino acid starvation
- apoptotic process
- apoptotic signaling pathway
- activation of cysteine-type endopeptidase activity involved in apoptotic process
Molecular Function
What the gene product does at the molecular level
- death domain binding