Zdhhc2 Gene Summary [Mouse]
Enables protein-cysteine S-myristoyltransferase activity; protein-cysteine S-palmitoyltransferase activity; and protein-cysteine S-stearoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation; protein localization to membrane; and synapse assembly. Acts upstream of or within postsynaptic neurotransmitter receptor cycle and protein palmitoylation. Located in plasma membrane; postsynaptic recycling endosome; and recycling endosome membrane. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; pancreas tip epithelium; and retina. Orthologous to human ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zdhhc2 |
| Official Name | zinc finger, DHHC domain containing 2 [Source:MGI Symbol;Acc:MGI:1923452] |
| Ensembl ID | ENSMUSG00000039470 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 2 |
| Synonyms | 5730415P04Rik, 6430583A19Rik, DHHC2, REAM, REC, srec, zinc finger, DHHC domain containing 2, zinc finger DHHC-type palmitoyltransferase 2, ZNF372 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-cysteine S-myristoyltransferase
- protein-cysteine S-acyltransferase
- palmitoyltransferase
- protein homodimerization
- protein-cysteine S-palmitoleyltransferase
- DHHC palmitoyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- COVID-19
- acute myeloid leukemia
- lung adenocarcinoma formation
- gastric adenocarcinoma
- lung adenocarcinoma
- organismal death
- gastric epithelial cancer
- Parkinson disease
role in cell
- expression in
- proliferation
- binding in
- palmitoylation in
- activation in
- autophagy in
- cell-cell contact
- angiogenesis by
- sunitinib resistance
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- cellular membrane
- Plasma Membrane
- endosomes
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
- endosomal membrane
- recycling endosomes
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein metabolic process
- synapse assembly
- regulation of cell-cell adhesion
- positive regulation of long-term synaptic potentiation
- regulation of neuronal synaptic plasticity
- peptidyl-L-cysteine S-palmitoylation
- regulation of protein catabolic process
- protein palmitoylation
- protein targeting to membrane
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic density
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum
- recycling endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- protein homodimerization activity
- protein-cysteine S-myristoyltransferase activity
- palmitoyltransferase activity