Trp53rka Gene Summary [Mouse]
Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Is expressed in embryo. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trp53rka |
| Official Name | transformation related protein 53 regulating kinase A [Source:MGI Symbol;Acc:MGI:1918294] |
| Ensembl ID | ENSMUSG00000039725 |
| Bio databases IDs | |
| Aliases | transformation related protein 53 regulating kinase A |
| Synonyms | 2810408M09Rik, BUD32, C20orf64, dJ101A2, GAMOS4, Nori-2, Nori-2p, PRPK, TP53 regulating kinase, TPRKB, transformation related protein 53 regulating kinase A, Trp53rka |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trp53rka often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- Kae1-associated kinase Bud32
- p53 binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Galloway-Mowat syndrome 4
- colorectal carcinomagenesis
- organismal death
- colorectal adenocarcinoma
- colorectal cancer
role in cell
- expression in
- phosphorylation in
- activation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trp53rka gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
- protein phosphorylation
- threonylcarbamoyladenosine metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- EKC/KEOPS complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- p53 binding
- protein binding
- protein serine/threonine kinase activity
- hydrolase activity