Ppm1l Gene Summary [Mouse]
Enables protein serine/threonine phosphatase activity. Acts upstream of or within MAPK cascade and cell surface receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including gut; limb segment; metanephros; nervous system; and sensory organ. Orthologous to human PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppm1l |
| Official Name | protein phosphatase 1 (formerly 2C)-like [Source:MGI Symbol;Acc:MGI:2139740] |
| Ensembl ID | ENSMUSG00000027784 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 (formerly 2C)-like |
| Synonyms | 3222401G13, 5930404J21RIK, mKIAA4175, PP2C, PP2CE, PP2C-epsilon, PP2C-ε, PPM1-LIKE, Ppp2ce, protein phosphatase 1 (formerly 2C)-like, protein phosphatase, Mg2+/Mn2+ dependent 1L, protein phosphatase, Mg2+/Mn2+ dependent, 1L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppm1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sigma factor PP2C-like phosphatases
- Protein phosphatase 2C
- protein serine/threonine phosphatase
- phosphatase
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Pathways
Biological processes and signaling networks where the Ppm1l gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- chronic lymphocytic leukemia
- myocardial fibrosis
- Kawasaki disease
role in cell
- phosphorylation in
- production in
- differentiation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppm1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- protein dephosphorylation
- transmembrane receptor protein serine/threonine kinase signaling pathway
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- metal ion binding
- myosin phosphatase activity