Pla2g6 Gene Summary [Mouse]
Enables calcium-independent phospholipase A2 activity; long-chain fatty acyl-CoA hydrolase activity; and serine hydrolase activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in several cellular components, including extracellular space; microtubule cytoskeleton; and nuclear speck. Predicted to be active in mitochondrion. Is expressed in 1st branchial arch maxillary component; olfactory placode; otic pit; and trunk somite. Used to study Parkinson's disease 14 and neurodegeneration with brain iron accumulation 2a. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g6 |
| Official Name | phospholipase A2, group VI [Source:MGI Symbol;Acc:MGI:1859152] |
| Ensembl ID | ENSMUSG00000042632 |
| Bio databases IDs | |
| Aliases | phospholipase A2, group VI |
| Synonyms | CA2+ INDEPENDENT PHOSPHOLIPASE A2, CaI-PLA2, GVI, GVI PLA2, INAD1, iPLA2, iPLA(2)beta, iPLA2 beta, iPLA2 GVIA, IPLA2-VIA, iPLA(2)β, IPLA2 β, NBIA2, NBIA2A, NBIA2B, PARK14, phospholipase A2 group VI, phospholipase A2, group VI, PLA2, PNPLA9, VI-PLA2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pla2g6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- protein kinase binding
- lysophospholipase
- Ankyrin repeats (3 copies)
- calcium-independent phospholipase A2
- enzyme
- protein binding
- identical protein binding
- phospholipase A2
- Ankyrin repeat
- Patatins and Phospholipases
- 1-alkyl-2-acetylglycerophosphocholine esterase
- ATP-dependent protein binding
- serine hydrolase
- hydrolase
- acyl-CoA hydrolase
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Pla2g6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Phagosome Formation
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- COVID-19
- infantile neuroaxonal dystrophy
- diabetes mellitus
- PLA2G6-related disorder
- hereditary spastic ataxia
- cutaneous melanoma
- neurodegeneration with brain iron accumulation
- gait disturbance
role in cell
- adhesion
- proliferation
- degeneration
- apoptosis
- expression in
- survival
- phagocytosis
- invasion
- migration
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- microtubule cytoskeleton
- Golgi region
- Extracellular Space
- cellular membrane
- Plasma Membrane
- endosomes
- Mitochondria
- cytosol
- mitochondrial inner membrane
- nuclear speckles
- sarcolemma
- peroxisomes
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pla2g6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- phosphatidylcholine catabolic process
- phosphatidic acid metabolic process
- cardiolipin acyl-chain remodeling
- platelet activating factor metabolic process
- antibacterial humoral response
- Fc-gamma receptor signaling pathway involved in phagocytosis
- positive regulation of ceramide biosynthetic process
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- cardiolipin biosynthetic process
- phosphatidylethanolamine catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- microtubule cytoskeleton
- nuclear speck
- mitochondrion
- cytosol
- pseudopodium
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- lysophospholipase activity
- identical protein binding
- calmodulin binding
- serine hydrolase activity
- protein binding
- calcium-independent phospholipase A2 activity
- 1-alkyl-2-acetylglycerophosphocholine esterase activity
- long-chain acyl-CoA hydrolase activity
- hydrolase activity