Ddx28 Gene Summary [Mouse]
Predicted to enable rRNA binding activity. Predicted to be involved in mitochondrial large ribosomal subunit assembly. Located in mitochondrion. Orthologous to human DDX28 (DEAD-box helicase 28). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx28 |
| Official Name | DEAD box helicase 28 [Source:MGI Symbol;Acc:MGI:1919236] |
| Ensembl ID | ENSMUSG00000045538 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 28 |
| Synonyms | 2410004K13Rik, DEAD-box helicase 28, MDDX28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA binding
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribonucleoprotein granule
- Mitochondria
- cytosol
- mitochondrial nucleoids
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx28 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- ribonucleoprotein granule
- mitochondrion
- cytosol
- nucleolus
- mitochondrial nucleoid
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- RNA helicase activity
- rRNA binding