Cavin2 Gene Summary [Mouse]
Predicted to enable phosphatidylserine binding activity and protein kinase C binding activity. Predicted to be involved in plasma membrane tubulation. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cytosol; membrane raft; and nucleoplasm. Predicted to be active in caveola and cytoplasm. Is expressed in several structures, including dorsal root ganglion; embryo mesenchyme; genitourinary system; sensory organ; and tongue. Orthologous to human CAVIN2 (caveolae associated protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cavin2 |
| Official Name | caveolae associated 2 [Source:MGI Symbol;Acc:MGI:99513] |
| Ensembl ID | ENSMUSG00000045954 |
| Bio databases IDs | |
| Aliases | caveolae associated 2 |
| Synonyms | caveolae associated 2, caveolae associated protein 2, PS-p68, SDPR, SDR, Serum deprivation response |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cavin2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- binding protein
- PTRF/SDPR family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- diabetic nephropathy
- gastric adenocarcinoma
- gastric epithelial cancer
- oxygen-induced retinopathy
- small cell lung cancer
- uterine leiomyoma
- leiomyomatosis
- gastric cancer
- plasma cell neoplasm
role in cell
- expression in
- production in
- invasion by
- tubulation in
- binding
- proliferation
- migration
- loss
- tubulation
- beta-oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- caveolae-derived endocytic vesicles
- Cytoplasm
- cell surface
- cytosol
- caveolae
- nucleoplasm
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cavin2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane tubulation
Cellular Component
Where in the cell the gene product is active
- caveola
- cytoplasm
- membrane raft
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- phosphatidylserine binding
- protein binding
- phospholipid binding