Cd3eap Gene Summary [Mouse]
Acts upstream of or within rRNA transcription. Located in nucleolus. Part of RNA polymerase I complex. Is expressed in several structures, including adrenal gland; aorta; genitourinary system; nervous system; and pancreas. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human POLR1G (RNA polymerase I subunit G). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd3eap |
| Official Name | CD3E antigen, epsilon polypeptide associated protein [Source:MGI Symbol;Acc:MGI:1917583] |
| Ensembl ID | ENSMUSG00000047649 |
| Bio databases IDs | |
| Aliases | CD3E antigen, epsilon polypeptide associated protein |
| Synonyms | 1190028F09, 2610103M17Rik, ASE, ASE-1, CAST, CD3EAP, LOC686776, PAF49, RGD1305916, RNA polymerase I subunit G, RPA34 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd3eap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CD3epsilon binding domain
- protein binding
- DNA-directed RNA polymerase I subunit RPA34.5
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd3eap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription initiation from RNA polymerase I promoter
- rRNA transcription
- transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component
Where in the cell the gene product is active
- RNA polymerase I transcription factor complex
- DNA-directed RNA polymerase I complex
- mitochondrion
- cytosol
- chromosome
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding