Zbtb33 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to act upstream of or within DNA-templated transcription. Located in nucleus. Is expressed in several structures, including bladder; central nervous system; early conceptus; eye; and gonad. Orthologous to human ZBTB33 (zinc finger and BTB domain containing 33). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb33 |
| Official Name | zinc finger and BTB domain containing 33 [Source:MGI Symbol;Acc:MGI:1927290] |
| Ensembl ID | ENSMUSG00000048047 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 33 |
| Synonyms | E130014G12Rik, Kaiso, LOC100910807, RGD1566309, zinc finger and BTB domain containing 33, ZNF348, ZNF-kaiso |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zbtb33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- double-stranded DNA binding
- Zinc-finger double domain
- BTB_POZ
- methyl-CpG binding
- BTB/POZ domain
- protein binding
- zinc finger domain
- sequence-specific DNA binding
- C2H2-type zinc finger
Pathways
Biological processes and signaling networks where the Zbtb33 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colitis
role in cell
- proliferation
- cell death
- expression in
- migration
- upregulation in
- cell cycle progression
- invasion by
- infiltration by
- depletion
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- centrosome
- microtubules
- midbody
- cytosol
- nucleoplasm
- nucleoli
- spindle fibers
- neuromuscular junctions
- synapse
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zbtb33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- Wnt receptor signaling pathway
- regulation of cytokine production
- regulation of immune system process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- methyl-CpG binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity