Foxo6 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in memory; positive regulation of dendritic spine development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including nervous system; olfactory epithelium; renal cortex; stomach; and thymus. Orthologous to human FOXO6 (forkhead box O6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxo6 |
| Official Name | forkhead box O6 [Source:MGI Symbol;Acc:MGI:2676586] |
| Ensembl ID | ENSMUSG00000052135 |
| Bio databases IDs | |
| Aliases | forkhead box O6 |
| Synonyms | FO681542.1, forkhead box O6, LOC100131908 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxo6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- Transactivation domain of FOXO protein family
- protein binding
- Forkhead domain
- FORKHEAD
Pathways
Biological processes and signaling networks where the Foxo6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- bipolar disorder
- cardiomyopathy
- pervasive developmental disorder
role in cell
- production in
- apoptosis
- proliferation
- expression in
- differentiation
- cellular infiltration by
- phosphorylation in
- transactivation in
- density
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxo6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of dendritic spine development
- memory
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity