Tln2 Gene Summary [Mouse]
Predicted to enable integrin binding activity. Predicted to be involved in cell-cell adhesion and presynaptic actin cytoskeleton organization. Located in fascia adherens and synapse. Is expressed in several structures, including brain; ganglia; heart; submandibular gland; and trigeminal nerve. Orthologous to human TLN2 (talin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tln2 |
| Official Name | talin 2 [Source:MGI Symbol;Acc:MGI:1917799] |
| Ensembl ID | ENSMUSG00000052698 |
| Bio databases IDs | |
| Aliases | talin 2 |
| Synonyms | 5730421P04Rik, AI507121, ILWEQ, LOC108351746, mKIAA0320, RGD1565416, talin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tln2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- I/LWEQ domain
- Ubl1_cv_Nsp3_N-like
- Talin, middle domain
- protein binding
- Pleckstrin homology-like domain
- Vinculin Binding Site
- FERM domain B-lobe
- N-terminal or F0 domain of Talin-head FERM
- FERM N-terminal domain
Pathways
Biological processes and signaling networks where the Tln2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- COVID-19
- Alzheimer disease
- opioid dependence
- osteoarthritis
- dystrophy
- tic disorder
- stuttering
- epithelial cancer
- renal clear cell adenocarcinoma
role in cell
- activation in
- proliferation
- migration
- expression in
- number
- attachment
- assembly
- stability
- paclitaxel sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- presynaptic regions
- cellular membrane
- focal adhesions
- costameres
- synapse
- intercalated disks
- cell-cell adherens junctions
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tln2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell junction assembly
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- actin cytoskeleton
- ruffle
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actin binding
- structural molecule activity
- structural constituent of cytoskeleton
- integrin binding