Klk13 Gene Summary [Mouse]

Kallikreins are serine proteases encoded by a cluster of highly related genes on chromosome 7. When genomic sequence became available, it was possible to clarify the gene-to-sequence relationship for this family. Until January, 2006, NM_010115 was called kallikrein 13. After that time, NM_001039042 was called Klk13 and NM_010115 was called Klk1b26. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
Klk13
Official Name
kallikrein related-peptidase 13 [Source:MGI Symbol;Acc:MGI:3615275]
Ensembl ID
ENSMUSG00000054046
Bio databases IDs NCBI: 626834 Ensembl: ENSMUSG00000054046
Aliases kallikrein related-peptidase 13
Synonyms Egfbp-2, kallikrein related-peptidase 13, KLK-L4, Klnl, mGk-13
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klk13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Trypsin-like serine protease
  • endopeptidase
  • trypsin
  • Tryp_SPc
  • peptidase
  • Domain of unknown function (DUF1986)
  • Trypsin-like peptidase domain
  • hydrolase
  • protein binding

Pathways

Biological processes and signaling networks where the Klk13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • atopic dermatitis
  • psoriasis
  • pruritus
regulated by
regulates
  • N-cadherin
role in cell
  • proliferation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • Cytoplasm
  • secretory granules

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Klk13 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • proteolysis
  • protein processing

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • cytoplasm
  • secretory granule
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • serine-type endopeptidase activity
  • hydrolase activity

Gene-Specific Assays for Results You Can Trust

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