Tug1 Gene Summary [Mouse]
Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including mitochondrion organization; photoreceptor cell development; and spermatogenesis. Located in cytoplasm. Is active in nucleus. Is expressed in several structures, including central nervous system; olfactory epithelium; retina; spleen; and testis. Orthologous to human TUG1 (taurine up-regulated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tug1 |
| Official Name | taurine upregulated gene 1 [Source:MGI Symbol;Acc:MGI:2144114] |
| Ensembl ID | ENSMUSG00000056579 |
| Bio databases IDs | |
| Aliases | taurine upregulated gene 1 |
| Synonyms | AI316828, FLJ20618, LINC00080, NCRNA00080, taurine up-regulated 1, taurine upregulated gene 1, TI-227, TI-227H |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tug1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- colorectal cancer
- vitiligo
- hepatocellular carcinoma
- organismal death
- liver cancer
- epithelial cancer
- laryngeal squamous cell carcinoma
- squamous cell cancer of the larynx
role in cell
- proliferation
- expression in
- cell viability
- apoptosis
- autophagy in
- number
- differentiation
- migration
- development
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm