Plce1 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity and small GTPase binding activity. Predicted to be involved in several processes, including glycerolipid metabolic process; intracellular signal transduction; and positive regulation of lamellipodium assembly. Predicted to be located in cytosol; lamellipodium; and plasma membrane. Is expressed in several structures, including central nervous system; facial bone primordium; olfactory epithelium; retina; and thymus. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Plce1 |
| Official Name | phospholipase C, epsilon 1 [Source:MGI Symbol;Acc:MGI:1921305] |
| Ensembl ID | ENSMUSG00000024998 |
| Bio databases IDs | |
| Aliases | phospholipase C, epsilon 1 |
| Synonyms | 4933403A21Rik, Gm3865, mKIAA1516, NPHS3, phospholipase C epsilon 1, phospholipase C, epsilon 1, phospholipase C ε 1, phospholipase C, ε 1, PLCE, PLCepsilon, Plc ε, PPLC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plce1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RA2 domain
- Phosphatidylinositol-specific phospholipase C, Y domain
- enzyme binding
- enzyme
- protein binding
- RasGEF
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- Cdc25 domain
- phospholipase C
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- phosphoinositide phospholipase C
- ras association domain
- Phospholipase C, catalytic domain (part: domain X)
- Ras-binding domain
- guanyl-nucleotide exchange factor
- Ubl1_cv_Nsp3_N-like
- Phospholipase C, catalytic domain (part: domain Y)
- guanine nucleotide exchange factor domain
- Protein kinase C conserved region 2 (CalB)
- cysteine rich domain
- C2 domain
Pathways
Biological processes and signaling networks where the Plce1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- Leptin Signaling in Obesity
- Melatonin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- endometriosis
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- benign neoplasia
- metastasis
- nephrotic syndrome type 3
role in cell
- expression in
- apoptosis
- phosphorylation in
- growth
- downregulation in
- activation in
- cell cycle progression
- proliferation
- binding in
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plce1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of lamellipodium assembly
- G-protein coupled receptor signaling pathway
- epidermal growth factor receptor signaling pathway
- diacylglycerol biosynthetic process
- phosphatidylinositol metabolic process
- Ras protein signal transduction
- phospholipase C-activating G-protein coupled receptor signaling pathway
- glomerulus development
- phosphatidylinositol-mediated signaling
- lipid catabolic process
- release of sequestered calcium ion into cytosol
- calcium-mediated signaling
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- Golgi membrane
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- metal ion binding
- phospholipase C activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding
- enzyme binding