Gmfb Gene Summary [Mouse]
Predicted to enable Arp2/3 complex binding activity. Acts upstream of or within learning and locomotory behavior. Predicted to be active in cortical actin cytoskeleton. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Orthologous to human GMFB (glia maturation factor beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gmfb |
| Official Name | glia maturation factor, beta [Source:MGI Symbol;Acc:MGI:1927133] |
| Ensembl ID | ENSMUSG00000062014 |
| Bio databases IDs | |
| Aliases | glia maturation factor, beta |
| Synonyms | 3110001H22Rik, 3110001O16Rik, D14Ertd630e, glia maturation factor beta, glia maturation factor, beta, glia maturation factor β, glia maturation factor, β, GMF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gmfb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cofilin/tropomyosin-type actin-binding protein
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- protein kinase inhibitor activity
- enzyme activator activity
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- preeclampsia
role in cell
- phosphorylation in
- expression in
- apoptosis
- cell death
- activation
- activity
- number
- oxidative stress response
- depolymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gmfb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- nervous system development
- actin filament debranching
- protein phosphorylation
- negative regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- actin binding
- enzyme activator activity
- protein kinase inhibitor activity
- Arp2/3 complex binding