Tnfaip8 Gene Summary [Mouse]
Enables molecular sequestering activity and small molecule binding activity. Acts upstream of or within defense response to Gram-positive bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including brain ventricular layer; choroid plexus; musculoskeletal system; respiratory system; and thymus primordium. Orthologous to human TNFAIP8 (TNF alpha induced protein 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfaip8 |
| Official Name | tumor necrosis factor, alpha-induced protein 8 [Source:MGI Symbol;Acc:MGI:2147191] |
| Ensembl ID | ENSMUSG00000062210 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor, alpha-induced protein 8 |
| Synonyms | E130304C20Rik, GG2-1, Gm10539, LOC100503858, MDC-3.13, NDED, SCC-S2, Ssc-2, Tipe, TNF alpha induced protein 8, TNF α induced protein 8, tumor necrosis factor, alpha-induced protein 8, tumor necrosis factor, α-induced protein 8, tumour necrosis factor, alpha-induced protein 8, tumour necrosis factor, α-induced protein 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfaip8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF758)
- binding protein
- caspase inhibitor activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- allergic rhinitis
- weight loss
- asthma
- respiratory disorder
- metastasis
- organismal death
- dextran sodium sulfate-induced colitis
- allergy
- male pattern hair loss
role in cell
- expression in
- growth
- cell viability
- cell death
- proliferation
- migration
- phosphorylation in
- apoptosis
- upregulation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfaip8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process