Gpbar1 Gene Summary [Mouse]
Predicted to enable G protein-coupled bile acid receptor activity. Involved in regulation of bicellular tight junction assembly. Predicted to be located in cytoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in gut and male reproductive gland or organ. Orthologous to human GPBAR1 (G protein-coupled bile acid receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpbar1 |
| Official Name | G protein-coupled bile acid receptor 1 [Source:MGI Symbol;Acc:MGI:2653863] |
| Ensembl ID | ENSMUSG00000064272 |
| Bio databases IDs | |
| Aliases | G protein-coupled bile acid receptor 1 |
| Synonyms | BG37, GPCR, GPCR19, GPR131, G protein-coupled bile acid receptor 1, M-BAR, TGR5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpbar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpbar1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic fibrosis
- obesity
- neurological disorder
- weight gain
- muscular hypertrophy
- steatohepatitis
- diabetes mellitus
- atherogenesis
- brain edema
- dextran sodium sulfate-induced colitis
regulated by
- 23,24-dinor-5beta-cholane-3alpha,7alpha,22-triol
- bile acid
- 24-nor-5beta-cholane-3alpha,7alpha,12alpha,23-tetrol
- 5-hydroxytryptamine
- taurodeoxycholic acid
- lithocholic acid
- 5beta-cholane-3alpha,7alpha,12alpha,24-tetrol
- 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol
- andrographolide
- INT-767
role in cell
- damage in
- expression in
- proliferation
- synthesis in
- differentiation
- phosphorylation in
- accumulation in
- activation in
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpbar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- regulation of tight junction assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding