mt-Cytb Gene Summary [Mouse]
Predicted to enable metal ion binding activity. Predicted to contribute to ubiquinol-cytochrome-c reductase activity. Predicted to be involved in several processes, including electron transport coupled proton transport; mitochondrial electron transport, ubiquinol to cytochrome c; and response to glucagon. Located in membrane and mitochondrion. Part of respiratory chain complex III. Is active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | mt-Cytb |
| Official Name | mitochondrially encoded cytochrome b [Source:MGI Symbol;Acc:MGI:102501] |
| Ensembl ID | ENSMUSG00000064370 |
| Bio databases IDs | |
| Aliases | mitochondrially encoded cytochrome b |
| Synonyms | CYTB, Cytob, cytochrome b, MITOCHONDRIAL CYTOCHROME B, mt-Cytb, Similar to cytochrome b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mt-Cytb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome_b_C
- ubiquinol-cytochrome-c reductase
- binding protein
- Cytochrome_b_N
- heme binding domain
- enzyme
- Cytochrome b(C-terminal)/b6/petD
Pathways
Biological processes and signaling networks where the Mt-Cytb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- infection
- HIV infection
- Leber optic atrophy
- Pneumocystosis jiroveci pneumonia
- malaria
- osteosarcoma
- osteosarcomagenesis
- parkinsonism/MELAS overlap syndrome
- ovarian neoplasia
role in cell
- binding in
- production in
- activation
- synthesis in
- ingestion by
- oxidative phosphorylation in
- mitochondrial import in
- glycolysis in
- carboxylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mt-Cytb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hyperoxia
- response to cobalamin
- electron transport coupled proton transport
- response to copper ion
- response to mercury ion
- cellular respiration
- response to cadmium ion
- response to xenobiotic stimulus
- mitochondrial electron transport, ubiquinol to cytochrome c
- response to toxin
- response to ethanol
- response to hypoxia
- response to calcium ion
- response to glucagon stimulus
- organ regeneration
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrion
- mitochondrial respiratory chain complex III
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ubiquinol-cytochrome-c reductase activity
- metal ion binding