Cnga1 Gene Summary [Mouse]
Predicted to enable cyclic nucleotide binding activity and intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Predicted to be involved in membrane depolarization; monoatomic cation transport; and regulation of cytosolic calcium ion concentration. Located in photoreceptor outer segment membrane and rod photoreceptor outer segment. Is expressed in photoreceptor layer outer segment; retina; and retina outer nuclear layer. Used to study retinitis pigmentosa 49. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 49. Orthologous to human CNGA1 (cyclic nucleotide gated channel subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnga1 |
| Official Name | cyclic nucleotide gated channel alpha 1 [Source:MGI Symbol;Acc:MGI:88436] |
| Ensembl ID | ENSMUSG00000067220 |
| Bio databases IDs | |
| Aliases | cyclic nucleotide gated channel alpha 1 |
| Synonyms | cGMP Gated Cation Channel, CNCG, CNCG1, CNG, CNG-1, CNG channel alpha 1, CNG channel α 1, Cyclic nucleotide-gated channel, cyclic nucleotide gated channel alpha 1, cyclic nucleotide gated channel subunit alpha 1, cyclic nucleotide gated channel subunit α 1, cyclic nucleotide gated channel α 1, HCN, RCNC1, RCNCa, RCNCalpha, Rcngc1, RP49 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnga1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cyclic nucleotide-binding domain
- C-terminal leucine zipper domain of cyclic nucleotide-gated channels
- Ion transport protein
- 3',5'-cAMP binding
- intracellular cGMP activated cation channel
- intracellular cAMP activated cation channel
- protein binding
- intracellular cyclic nucleotide activated cation channel
- ion channel
- CAP_ED
- 3',5'-cGMP binding
- Cyclic nucleotide-monophosphate binding domain
Pathways
Biological processes and signaling networks where the Cnga1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cold allodynia
- retinitis pigmentosa type 49
- retinitis pigmentosa
- androgenic alopecia
- autosomal recessive retinitis pigmentosa
- retinal dystrophy
- cone-rod dystrophy
- systemic lupus erythematosus
- CNGA1-related retinopathy
- right colon cancer
regulates
- AKT
- MTOR
- PI3K (complex)
role in cell
- cell death
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- photoreceptor outer segments
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnga1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- calcium ion transport
- calcium ion transmembrane transport
- sodium ion transmembrane transport
- visual perception
Cellular Component
Where in the cell the gene product is active
- intracellular cyclic nucleotide activated cation channel complex
- plasma membrane
- photoreceptor outer segment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium channel activity
- sodium channel activity
- intracellular cAMP activated cation channel activity
- cAMP binding
- cGMP binding
- intracellular cGMP activated cation channel activity