Drosha Gene Summary [Mouse]
Enables RNA endonuclease activity and primary miRNA binding activity. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including RNA metabolic process; regulation of miRNA metabolic process; and regulation of regulatory T cell differentiation. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; hemolymphoid system gland; and tooth. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Drosha |
| Official Name | drosha, ribonuclease type III [Source:MGI Symbol;Acc:MGI:1261425] |
| Ensembl ID | ENSMUSG00000022191 |
| Bio databases IDs | |
| Aliases | drosha, ribonuclease type III |
| Synonyms | 1110013A17Rik, drosha ribonuclease III, drosha, ribonuclease type III, ETOHI2, HSA242976, RANSE3L, RGD1307626, RN3, RNASE3L, RNASEN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Drosha often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- SMAD binding
- double-stranded RNA binding motif (DSRM) superfamily
- ribonuclease III, bacterial
- enzyme
- protein binding
- lipopolysaccharide binding
- proline rich domain
- RNA binding
- Double-stranded RNA binding motif
- ribonuclease III
- DEAD/H-box RNA helicase binding
- protein homodimerization
- endoribonuclease
- dsRNA-binding domain
- RIBOc
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- papillomatosis
- metastasis
- esophageal squamous cell carcinoma
- head and neck cancer
- brain cancer
- endocrine cancer
- head and neck neoplasia
- central nervous system cancer
role in cell
- proliferation
- cell death
- quantity
- expression in
- growth
- migration
- invasion by
- molecular cleavage in
- processing in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- cytosol
- nucleoplasm
- postsynaptic density
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Drosha gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of miRNA metabolic process
- primary miRNA processing
- defense response to Gram-negative bacterium
- pre-miRNA processing
- positive regulation of gene expression
- regulation of inflammatory response
- regulation of regulatory T cell differentiation
- rRNA processing
- defense response to Gram-positive bacterium
- miRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- nucleus
- cytosol
- nucleolus
- microprocessor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease III activity
- protein homodimerization activity
- protein binding
- RNA binding
- SMAD binding
- metal ion binding
- DEAD/H-box RNA helicase binding
- R-SMAD binding
- primary miRNA binding
- lipopolysaccharide binding