Wnt2 Gene Summary [Mouse]
Predicted to enable cytokine activity and frizzled binding activity. Involved in cell proliferation in midbrain and positive regulation of neurogenesis. Acts upstream of or within several processes, including circulatory system development; lung induction; and positive regulation of cell population proliferation. Predicted to be located in collagen-containing extracellular matrix; cytoplasm; and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including embryo mesenchyme; heart and pericardium; reproductive system; upper jaw primordium; and urethra. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt2 |
| Official Name | wingless-type MMTV integration site family, member 2 [Source:MGI Symbol;Acc:MGI:98954] |
| Ensembl ID | ENSMUSG00000010797 |
| Bio databases IDs | |
| Aliases | wingless-type MMTV integration site family, member 2 |
| Synonyms | 2610510E18Rik, INT1L1, IRP, Mirp, wingless-type MMTV integration site family, member 2, Wnt, Wnt2a, Wnt family member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wnt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- frizzled binding
- wnt family
- receptor agonist activity
- protein binding
- cytokine
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine serous papillary cancer
- colorectal cancer
- organismal death
- colorectal carcinomagenesis
- Dupuytren contracture
- non-small cell lung cancer
- uterine leiomyoma
- leiomyomatosis
- nonalcoholic fatty liver disease
- lung adenocarcinoma formation
role in cell
- aggregation
- apoptosis
- morphology
- proliferation
- accumulation in
- development
- size
- accumulation
- transformation
- proliferation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wnt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- positive regulation of cell proliferation
- neurogenesis
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- lens development in camera-type eye
- positive regulation of epithelial cell proliferation involved in lung morphogenesis
- epithelial cell proliferation involved in lung morphogenesis
- positive regulation of fibroblast proliferation
- mammary gland epithelium development
- canonical Wnt receptor signaling pathway
- cell proliferation in midbrain
- atrial cardiac muscle tissue morphogenesis
- lung induction
- neuron differentiation
- cell-cell signaling
- cardiac epithelial to mesenchymal transition
- positive regulation of mesenchymal cell proliferation
- cardiac muscle cell proliferation
- cellular response to transforming growth factor beta stimulus
- labyrinthine layer blood vessel development
- cellular response to retinoic acid
- cell fate commitment
- iris morphogenesis
- positive regulation of neurogenesis
- mesenchymal cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- receptor agonist activity
- cytokine activity