3425401B19Rik Gene Summary [Mouse]
Involved in positive regulation of calcineurin-NFAT signaling cascade. Acts upstream of or within cardiac muscle cell contraction; cardiac muscle cell differentiation; and heart morphogenesis. Located in Z disc. Is expressed in several structures, including aorta; gut; heart; lung; and spleen. Used to study dilated cardiomyopathy. Orthologous to human C10orf71 (chromosome 10 open reading frame 71). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | 3425401B19Rik |
| Official Name | RIKEN cDNA 3425401B19 gene [Source:MGI Symbol;Acc:MGI:3588196] |
| Ensembl ID | ENSMUSG00000071540 |
| Bio databases IDs | |
| Aliases | RIKEN cDNA 3425401B19 gene |
| Synonyms | 3425401B19Rik, C10orf71 homolog, C16h10orf71, CEFIP, chromosome 10 open reading frame 71, RGD1564899, RIKEN cDNA 3425401B19 gene, similar to human chromosome 10 open reading frame 71 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse 3425401b19rik often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4585)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse 3425401b19rik gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of calcineurin-NFAT signaling cascade
Cellular Component
Where in the cell the gene product is active
- Z disc
Molecular Function
What the gene product does at the molecular level
- protein binding