Flt3l Gene Summary [Mouse]
Enables receptor tyrosine kinase binding activity. Involved in B cell differentiation; dendritic cell differentiation; and natural killer cell differentiation. Acts upstream of or within several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in colon carcinoma; glioblastoma; high grade glioma; and immunodeficiency 125. Orthologous to human FLT3LG (fms related receptor tyrosine kinase 3 ligand). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Flt3l |
| Official Name | FMS-like tyrosine kinase 3 ligand [Source:MGI Symbol;Acc:MGI:95560] |
| Ensembl ID | ENSMUSG00000110206 |
| Bio databases IDs | |
| Aliases | FMS-like tyrosine kinase 3 ligand |
| Synonyms | FL, FLG3L, FLT3L, FLT3 LIGAND, FMS-like tyrosine kinase 3 ligand, Fms related receptor tyrosine kinase 3 ligand, FMS-RELATED TYROSINE KINASE 3 LIGAND, Gm45713, IMD125, LOC102547607, LOC103691111, Ly72L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flt3l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor tyrosine kinase binding
- flt3 ligand
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Flt3l gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- cancer
- epithelial cancer
- neoplasia
- rheumatoid arthritis
- delayed hypersensitive reaction
- androgenic alopecia
- hypoplasia
- cardiac hypertrophy
- vasculitis
role in cell
- expression in
- quantity
- activation in
- apoptosis
- proliferation
- survival
- phosphorylation in
- cell viability
- synthesis in
- priming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flt3l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic hemopoiesis
- signal transduction
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- cytosol
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity
- receptor binding
- receptor tyrosine kinase binding